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Correlative immune-cytokine biomarker analysis from a phase 1 trial of oncolytic virus TILT-123 plus IL-2-free TIL therapy in checkpoint-inhibitor-resistant metastatic melanoma, published in J Immunother Cancer. Identifies an immune signature associated with survival, offering hypothesis-generating insight but not yet an actionable predictive marker for treatment selection.
Large propensity-matched retrospective cohort study using a federated EHR network, published in Research and Practice in Thrombosis and Haemostasis, comparing thrombotic and bleeding risk between first-line ipilimumab/nivolumab and BRAF/MEK inhibitors in advanced melanoma. Suggests higher VTE risk with combination immunotherapy, which could inform risk counseling and monitoring when choosing between these regimens.
Translational analysis of a phase 3 adjuvant ipilimumab melanoma trial, published in Melanoma Research, identifying germline SNPs associated with immune-related dermatitis risk and severity, with dermatitis occurrence linked to improved relapse-free survival. Offers early insight into genetic predictors of ICI skin toxicity but does not yet inform a specific treatment decision.
Retrospective single-center cohort study of patients receiving lifileucel TIL therapy for advanced melanoma, published in JCO Oncology Practice. Characterizes outpatient toxicity and readmission after discharge, informing follow-up and monitoring practices for this growing therapy.